Symbol
Name
ID

Tap2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
MGI:98484

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes

Leukopenia

Chronic sinusitis

Pericarditis

Lymphadenopathy

Chronic otitis media

Lupus nephritis

Nephritis

Abnormality of the immune system

Discoid lupus rash

Malar rash

Serositis

Decreased circulating complement C3 concentration

Decreased circulating complement C4 concentration

Autoimmunity

Anti-citrullinated protein antibody positivity

Antineutrophil antibody positivity

Perinuclear antineutrophil antibody positivity

Antinuclear antibody positivity

Anti-dsDNA antibody positivity

Anti-La/SS-B antibody positivity

Anti-Sm antibody positivity

Anti-U1 ribonucleoprotein antibody positivity

Antiphospholipid antibody positivity

Rheumatoid factor positive

Systemic lupus erythematosus

Bronchiolitis

Recurrent bronchitis

Disease(s) Associated with TAP2

MHC class I deficiency

rheumatoid arthritis

systemic lupus erythematosus

type 1 diabetes mellitus

Mouse Phenotypes

decreased effector memory CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

absent CD8-positive, alpha-beta T cells

decreased NK T cell number

abnormal NK cell physiology

abnormal cytotoxic T cell physiology

decreased level of surface class I molecules

defective assembly of class I molecules

Availability

Mouse Genotype

Tap2^jas/Tap2^jas

Tap2^m1Btlr/Tap2^m1Btlr

Tap2^m2Btlr/Tap2^m2Btlr

Tap2^m3Btlr/Tap2^m3Btlr

Tap2^M4Btlr/Tap2^M4Btlr

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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